Alzheimer's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Alzheimer's Disease, including details on diagnosis, memory loss, heredity, treatment, medication.

Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models.

Wirths O, Bayer TA

Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Goettingen, Germany. owirths@uni-goettingen.de

In this commentary, we accent the accumulating evidence for motor impairment as a common feature of early Alzheimer's disease (AD) pathology. In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD-associated genes like tau or amyloid precursor protein.

Published 10 January 2008 in Genes Brain Behav, 7: 1-5.
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