Alzheimer's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Alzheimer's Disease, including details on diagnosis, memory loss, heredity, treatment, medication.

EPR study of the interactions between dendrimers and peptides involved in Alzheimer's and prion diseases.

Klajnert B, Cangiotti M, Calici S, Majoral JP, Caminade AM, Cladera J, Bryszewska M, Ottaviani MF

Department of General Biophysics, University of Lodz, 12/16 Banacha St., 90-237 Lodz, Poland.

Spin-probe and spin-label techniques were used to study the interactions of the Abeta 1-28 peptide involved in Alzheimer disease and the PrP 106-126 peptide suspected to be preferentially involved in spongiform encephalopathies with three different types of dendrimers. A computer-aided EPR analysis of a positively charged and a neutral spin probe was performed by comparing the pure dendrimer and peptide systems with the dendrimer-peptide ones. Also spin-labeled PAMAM dendrimers were used to test the interactions. The results show the interactions between dendrimer and peptide monomer to be stronger for Abeta 1-28 than for PrP 106-126. PAMAM dendrimers perturb the aggregation of the peptides more than PPI dendrimers do.

Published 13 August 2007 in Macromol Biosci, 7(8): 1065-74.
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