Alzheimer's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Alzheimer's Disease, including details on diagnosis, memory loss, heredity, treatment, medication.

Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner.

Burgos JS, Ramirez C, Sastre I, Valdivieso F

NEURON BioPharma, Drug Discovery Unit, Edificio BIC, Armilla, Granada, Spain. jburgos@neuronbp.com

There is growing evidence that herpes simplex virus type 1 (HSV-1), together with the apolipoprotein E 4 (APOE4) allele, contribute to the pathogenesis of Alzheimer's disease (AD), although the mechanism of their interaction remains uncertain. Here we show that the combination of inherited APOE genotype and vertical transmission of HSV-1 confers a differential risk of brain infection. These risk factors are known to be associated with AD.

Published 16 November 2007 in Aging Cell, 6(6): 841-2.
Full-text of this article is available online (may require subscription).

© 2004-2008 Alzheimer's Disease Research Today. All Rights Reserved.