Alzheimer's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Alzheimer's Disease, including details on diagnosis, memory loss, heredity, treatment, medication.

Treatment monitoring and response prediction with proton MR spectroscopy in AD.

Jessen F, Traeber F, Freymann K, Maier W, Schild HH, Block W

Department of Psychiatry, University of Bonn, Germany. jessen@uni-bonn.de

In this proton magnetic resonance spectroscopy ((1)H-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate (NAA) level and NAA/Creatine (Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome.

Published 8 August 2006 in Neurology, 67(3): 528-30.
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