Alzheimer's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Alzheimer's Disease, including details on diagnosis, memory loss, heredity, treatment, medication.

Environmental reduplicative paramnesia in a case of atypical Alzheimer's disease.

von Gunten A, Miklossy J, Suvà ML, Hof PR, Glannakopoulos P

Service Universitaire de Psychiatrie de l' Age Avancé, Centre Hospitalier Universitaire Vandois, Lausanne, Switzerland. armin.von-gunten@inst.hospvd.ch

A 79-year-old patient with neuropathologically confirmed Alzheimer's disease (AD) presented with a selective environmental reduplicative paramnesia (RP), the belief that one or more environments exist simultaneously in two or more physical locations. Clinical presentation and neuropathological examination revealed an atypical form of AD. High neurofibrillary tangle densities were observed in the frontal and temporal association cortex, whereas the parietal and entorhinal cortex, as well as the hippocampus, were nearly spared. These findings are compared to those reported in frontal and frontotemporal variants of AD and discussed in the light of current anatomoclinical models for environmental RP.

Published 11 July 2005 in Neurocase, 11(3): 216-26.
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