Alzheimer's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Alzheimer's Disease, including details on diagnosis, memory loss, heredity, treatment, medication.

CH/pi hydrogen bonds as evidenced in the substrate specificity of acetylcholine esterase.

Umezawa Y, Nishio M

Microbial Chemistry Research Center, Shinagawa-ku, Tokyo 141-0021, Japan. umezaway@bikaken.or.jp

The crystal structure of acetylcholine esterase (AchE) in complex with various inhibitors, investigated as drugs for improvement of the cognitive ability of early stage Alzheimer's disease, has been analyzed with the use of our program CHPI. A number of CH/pi hydrogen bonds have been disclosed in the binding of the inhibitors with Torpedo californica AchE. It has been demonstrated that, in order to be effective in the binding with AchE, C-H bonds in the inhibitor need not be polarized.

Published 2 November 2005 in Biopolymers, 79(5): 248-58.
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