Alzheimer's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Alzheimer's Disease, including details on diagnosis, memory loss, heredity, treatment, medication.

Plasma clusterin and the risk of Alzheimer disease.

Schrijvers EM, Koudstaal PJ, Hofman A, Breteler MM

Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

Published 6 April 2011 in JAMA, 305(13): 1322-6.
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Articles on Alzheimer's Disease published 6 April 2011:

Plasma clusterin and the risk of Alzheimer disease.   JAMA, 305(13): 1322-6.

[Abstract] [Full-text]

Plasma clusterin and the risk of Alzheimer disease.   JAMA, 305(13): 1322-6.

[Abstract] [Full-text]

Articles on Alzheimer's Disease published 22 March 2011:

Alzheimer's disease.   Lancet, 377(9770): 1019-31.

An estimated 24 million people worldwide have dementia, the majority of whom are thought to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health concern and has been identified as a research priority. Although there are licensed treatments that can alleviate symptoms of Alzheimer's disease, there is a pressing need to improve our understanding of pathogenesis to enable development of disease-modifying treatments. Methods for improving diagnosis are also moving ... [Abstract] [Full-text]

Articles on Alzheimer's Disease published 16 March 2011:

Hippocampal morphometry in population-based incident Alzheimer's disease and vascular dementia: the HAAS.   J Neurol Neurosurg Psychiatry, 82(4): 373-6.

[Abstract] [Full-text]

Loss of basic lexical knowledge in old age.   J Neurol Neurosurg Psychiatry, 82(4): 369-72.

[Abstract] [Full-text]

Articles on Alzheimer's Disease published 11 March 2011:

Tau haplotypes and ApoE4 do not act in synergy on Alzheimer's disease.   Psychiatry Res, 186(2): 448-50.

There are conflicting results regarding the role of tau (MAPT) haplotypes in neurodegenerative disorders. Recent reports suggest that ethnicity factors and gene-gene interactions may influence the risk of developing Alzheimer's disease (AD). The present study investigates possible synergism between MAPT haplotype and ApoE state in Hungarian Caucasian AD cases (n=91) and control (n=83) population. The difference in MAPT H1 allele frequency did not reach significant level in AD (78%), and control ... [Abstract] [Full-text]

Articles on Alzheimer's Disease published 1 March 2011:

Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia.   Arch Intern Med, 171(4): 333-9.

[Abstract] [Full-text]

Articles on Alzheimer's Disease published 21 February 2011:

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons.   Biochim Biophys Acta, 1812(4): 507-13.

Loss of synapses and synaptic damage are the best correlates of cognitive decline identified in patients with Alzheimer's disease (AD), and mitochondrial oxidative damage and synaptic pathology have been identified as early events in the progression of AD. The progressive accumulation of amyloid beta (Aβ) in synapses and synaptic mitochondria are hypothesized to cause synaptic degeneration and cognitive decline in patients with AD. However, the precise mechanistic link between Aβ and ... [Abstract] [Full-text]

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